This book discusses contemporary constellations of international politics and global transformation. It offers guidance on how to conceptualize the complexity of current global changes and practical policy advice in order to promote an open global society. In the light of today's challenges, the author re-interprets the main argument of the philosopher Karl Popper in "The Open Society and Its Enemies". Based on this framework and new empirical evidence, the book discusses the thesis of an ongoing Third World War, triggered by fundamental deficits in nation-building, occurring primarily within states and not between them, and accelerated by asymmetric forms of warfare and Islamist totalitarianism.